Deep learning is expected to aid pathologists by automating tasks such as tumour segmentation. We aimed to develop one universal tumour segmentation model for histopathological images and examine its performance in different cancer types. The model was developed using over 20 000 whole-slide images from over 4 000 patients with colorectal, endometrial, lung, or prostate carcinoma. Performance was validated in pre-planned analyses on external cohorts with over 3 000 patients across six cancer types. Exploratory analyses included over 1 500 additional patients from The Cancer Genome Atlas. Average Dice coefficient was over 80% in all validation cohorts with en bloc resection specimens and in The Cancer Genome Atlas cohorts. No loss of performance was observed when comparing the universal model with models specialised on single cancer types. In conclusion, extensive and rigorous evaluations demonstrate that generic tumour segmentation by a single model is possible across cancer types, patient populations, sample preparations, and slide scanners.

Purpose: To evaluate the quality of deep learning reconstruction for prospectively accelerated intraoperative magnetic resonance imaging (iMRI) during resective brain tumor surgery. Materials and Methods: Accelerated iMRI was performed during brain surgery using dual surface coils positioned around the area of resection. A deep learning (DL) model was trained on the fastMRI neuro dataset to mimic the data from the iMRI protocol. Evaluation was performed on imaging material from 40 patients imaged between 01.11.2021 - 01.06.2023 that underwent iMRI during tumor resection surgery. A comparative analysis was conducted between the conventional compressed sense (CS) method and the trained DL reconstruction method. Blinded evaluation of multiple image quality metrics was performed by two working neuro-radiologists and a working neurosurgeon on a 1 to 5 Likert scale (1=non diagnostic, 2=poor, 3=acceptable, 4=good, 5=excellent), and the favored reconstruction variant. Results: The DL reconstruction was strongly favored or favored over the CS reconstruction for 33/40, 39/40, and 8/40 of cases for reader 1, 2, and 3, respectively. Two of three readers consistently assigned higher ratings for the DL reconstructions, and the DL reconstructions had a higher score than their respective CS counterparts for 72%, 72%, and 14% of the cases for reader 1, 2, and 3, respectively. Still, the DL reconstructions exhibited shortcomings such as a striping artifact and reduced signal. Conclusion: DL shows promise to allow for high-quality reconstructions of intraoperative MRI with equal to or improved perceived spatial resolution, signal-to-noise ratio, diagnostic confidence, diagnostic conspicuity, and spatial resolution compared to compressed sense.

This paper presents a novel Inter Catchment Wastewater Transfer (ICWT) method for mitigating sewer overflow. The ICWT aims at balancing the spatial mismatch of sewer flow and treatment capacity of Wastewater Treatment Plant (WWTP), through collaborative operation of sewer system facilities. Using a hydraulic model, the effectiveness of ICWT is investigated in a sewer system in Drammen, Norway. Concerning the whole system performance, we found that the S{\o}ren Lemmich pump station plays a vital role in the ICWT framework. To enhance the operation of this pump station, it is imperative to construct a multi-step ahead water level prediction model. Hence, one of the most promising artificial intelligence techniques, Long Short Term Memory (LSTM), is employed to undertake this task. Experiments demonstrated that LSTM is superior to Gated Recurrent Unit (GRU), Recurrent Neural Network (RNN), Feed-forward Neural Network (FFNN) and Support Vector Regression (SVR).

Understanding the behavior of sewer system through proper urban hydrological models is an effective method of enhancing sewer system management. Conventional deterministic methods, which heavily rely on physical principles, is inappropriate for real-time purpose due to their expensive computation. On the other hand, data-driven methods have gained huge interests, but most studies only focus on modeling a single component of the sewer system and supply information at a very abstract level. In this paper, we proposed the DeepCSO model, which aims at forecasting CSO events from multiple CSO structures simultaneously in near real time at a citywide level. The proposed model provided an intermediate methodology that combines the flexibility of data-driven methods and the rich information contained in deterministic methods while avoiding the drawbacks of these two methods. A comparison of the results demonstrated that the deep learning based multi-task model is superior to the traditional methods. Keywords: Combined sewer overflow; Long short-term memory; Deep learning; Urban hydrological model; Multi-task learning Author names and affiliations: Duo Zhang (corresponding author): Ph.D. candidate, Faculty of Science and Technology, Norwegian University of Life Sciences, 1432, Ås, Norway.

Exploiting capacity of sewer system using decentralized control is a cost effective mean of minimizing the overflow. Given the size of the real sewer system, exploiting all the installed control structures in the sewer pipes can be challenging. This paper presents a divide and conquer solution to implement decentralized control measures based on unsupervised learning algorithms. A sewer system is first divided into a number of subcatchments. A series of natural and built factors that have the impact on sewer system performance is then collected. Clustering algorithms are then applied to grouping subcatchments with similar hydraulic hydrologic characteristics. Following which, principal component analysis is performed to interpret the main features of sub-catchment groups and identify priority control locations. Overflows under different control scenarios are compared based on the hydraulic model. Simulation results indicate that priority control applied to the most suitable cluster could bring the most profitable result.